380 Second Avenue, a Class B office building in close proximity to Union Square, New York City.

Image via Google Street View

Address: 380 Second Avenue Class: B
Cross Streets: First & Second Avenues Size: 198,000 SF
Year built: 1909 Architect: N/A

The office building at 380 Second Avenue in Midtown South was completed back in 1909 and known as the Gramercy Medical Arts and Education Building. The charming property is located just steps away from Gramercy Park, in an affluent yet quiet neighborhood that attracts many healthcare-related businesses and legal practices. The building is currently home to a high-profile tenant roster that includes renowned medical and educational organizations.

198 KSF of Class B Gramercy Park Office Space

380 Second Avenue offers 198,000 square feet of Class B Gramercy Park office space across its ten stories. Originally built in 1909, the property has been renovated over the years. It boasts amenities such as 24-hour access, biotech/lab space, concierge service, on-site property management and security, high ceilings, and tenant-controlled HVAC. Additionally, the building incorporates 300-pound floor loads, two handicapped-accessible lobbies, and a private loading dock on 22nd Street. Lawrence Zirinsky Associates owns the building, with ABS Partners in charge of property management.

Getting to and from 380 Second Avenue

380 Second Avenue benefits from an excellent location in the heart of Gramercy Park, steps away from Union Square and Madison Square Park. Those working in the building have easy access to a plethora of shopping and dining destinations in the area and several bus and subway stations. The neighborhood is a hotspot for healthcare-related businesses, with several leading Midtown hospitals and higher education institutions located nearby.

Who is renting office space at 380 Second Avenue?

380 Second Avenue is an ideal fit for healthcare-related businesses and medical practitioners. Notable tenants occupying office space in the building include Gramercy Surgery Center, NYU Langone Health, MedRite, NYU’s Department of Physical Therapy and College of Dentistry, Mt. Sinai’s New York Eye & Ear Infirmary, and the School of Visual Arts.

How much is the rent price for office space at 380 Second Avenue?

Office asking rents at 380 Second Avenue start around $60 per square foot but can vary depending on the terms and size of the lease. By comparison, average asking rents in Midtown Manhattan hover above $80 per square foot and can go even higher for Class A office properties.

Available Space

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Building Location & Nearby Public Transportation

Nearby Transportation


East 23rd Street & 1st Avenue - 3 minutes Walk
East 23rd Street & Lexington Avenue - 7 minutes Walk
2nd Avenue & East 25th Street - 4 minutes Walk
1 Av & E 25 St - 6 minutes Walk
2nd Avenue & East 23rd Street - 1 minute Walk
2nd Avenue & East 28th Street - 8 minutes Walk
1st Avenue & East 23rd Street - 4 minutes Walk

Important Information

Listings are presented for illustrative purposes only; they may no longer be available and are provided merely as an exemplary representation of the types of spaces in a given neighborhood for a given price.